[Progressive radiation-induced rectal injury: is there an opportunity to get out of a vicious circle? A clinical case].

Radiation therapy is one of the main treatment option for prostate cancer used either independently or as a component of combined and complex treatment of the disease. Modern achievements make it possible to deliver doses of radiation that match the exact dimensions of the tumor for greater efficacy, with minimal exposure of the surrounding tissues, however, does not eliminate them. In most patients, clinical manifestations of chronic radiation proctitis occur during the first 2 years after radiation therapy. The article summarizes the current knowledge about pathophysiology, clinical manifestations, diagnostics and treatment options for this condition. In this paper, we present a case of complicated of chronic radiation proctitis.

[Liver cirrosis and complication risk management].

Liver cirrhosis (LC) takes the main place in the structure of the pathology of the digestive system in terms of the frequency of mortality, as well as in the development of fatal and poorly controlled complications, which requires the search for effective methods for preventing the progression of the disease and the development of complications. The article provides updated information on the role of the intestinal microbiota, as well as endotoxemia and increased intestinal permeability syndromes in the pathophysiology of LC and its complications. The results of recent meta-analyses of the impact of dysbiotic disorders on the prognosis of the LC and the options for their correction are presented. Understanding of the significance of involvement of gut microbiota in the pathogenesis of LC has become one of the levers of management of the risks of complications of LC. In this case, the livergut axis can be considered to be the leading link to the formation of most of the main complications of LC.

[Psychosomatic correlations and autonomic regulation of systemic hemodynamics in peptic ulcer in people of the European North of the Russian Federation]. / Psikhosomaticheskie sootnosheniia i vegetativnaia reguliatsiia sistemnoi gemodinamiki pri iazvennoi bolezni u zhitelei Evropeiskogo Severa.

The examination of 71 patients with ulcer has established correlations between psychological status of the patients (personality and reactive anxiety, neurotism, type of personality response to the disease) and numerous clinical characteristics of the diseases. Features of vegetative regulation of systemic hemodynamics in ulcer northerners and correlations between vegetative tonicity and psychological status of the patients are characterized.

[Psychosomatic correlations and autonomic regulation of functions in peptic ulcer in inhabitants of the European North of the Russian Federation]. / Psikhosomaticheskie sootnosheniia i vegetativnaia reguliatsiia funktsii pri iazvennoi bolezni u zhitelei Evropeiskogo Severa.

The study of 71 patients with ulcer disease has found correlations between psychological status (personality and reactive anxiety, neurotism, type of personality response to the disease) and many clinical symptoms of the disease. Autonomic regulation features in ulcer citizens of the European North, correlations between vegetative tone and psychological status of the patients are characterized.

[Clinical and psychological features of the course of peptic ulcers in servicemen under conditions of northern Europe]. / Kliniko-psikhologicheskie osobennosti techeniia iazvennoi bolezni u voennosluzhashchikh v usloviiakh Evropeiskogo severa.

The investigation of 198 servicemen suffered from peptic ulcer has revealed the clinical specific features of disease course and specific character of relapse season. The multiple correlation between such parameters of psychological status as personal anxiety, neurotism, emotional non-stability and frustration tension were established. The leading type of attitude to one's own disease (ergopatic) conditioned by high level of realizing the social needs and by the aspiration for maintaining the professional status.

[Specific features of ulcer disease in sailors of the North Sea basin]. / Osobennosti techeniia iazvennoi bolezni u moriakov i rybakov Severnogo basseina.

The course of ulcer disease (UD) in sailors of the North seas was analysed and compared to that in non-sailors. UD in sailors runs with less pronounced subjective symptoms, manifests at younger age, is frequently accompanied by duodenal mucosa erosions and duodenogastric reflux. The greatest number of UD exacerbations was observed in the first month in sea and two months after getting home. Because of the fear to lose the job the sailors often do not seek medical assistance in spite of ulcer symptoms and this results in many cases of late diagnosis.